sr9009 peptide Induces weight loss in diet-induced obese mice - SR9009cancer is used for weight loss, diabetes, to improve athletic performance SR9009 Peptide: Understanding its Role as a REV-ERB Agonist

Stenabolic (SR9009) SR9009 peptide, also widely recognized by its trade name Stenabolic, is a synthetic compound that has garnered significant attention in scientific research circlesIdentification of a small molecule SR9009 that activates NRF2 ... - NIH. Its primary mechanism of action involves acting as a potent REV-ERB agonist. REV-ERBs are a family of nuclear receptors that play a crucial role in regulating various physiological processes, including circadian rhythms, metabolism, and inflammation. Understanding the interactions of SR9009 with these receptors is key to comprehending its potential applications and effects.

Developed by Professor Thomas Burris at the Scripps Research Institute, SR9009 is specifically designed to activate the REV-ERB alpha (REV-ERBα) and REV-ERB beta (REV-ERBβ) isoforms. Research indicates that SR9009 exhibits potent in vivo activity, influencing metabolism and the viability of tumor cells. Its efficacy as a REV-ERB agonist is quantified by its IC50 values, which are approximately 670 nM for REV-ERBα and 800 nM for REV-ERBβ.作者：ZN Huang·2024·被引用次数：13—SR9009, as an agonist of NR1D1 synthesis, is non-toxic and shows extensive protective effects in vivo, such as regulating lipid metabolism. ... In ... This means SR9009 binds to and increases the constitutive repression of genes regulated by these nuclear receptors作者：PM Wagner·2019·被引用次数：51—A synthetic pyrrole derivative (SR9009) that acts as REV-ERBs-specific agonists exhibits potent in vivo activity on metabolism and tumor cell viability..

One of the most extensively studied effects of SR9009 is its impact on metabolic pathways. Scientific literature points to its ability to improve both fatty acid oxidation and glucose metabolism.Induces weight loss in diet-induced obese mice. Brain penetrant. Compound Libraries for SR 9009. SR 9009 is also offered as part of the Tocriscreen 2.0 Max. This dual action is significant because it can prevent excess glucose from being converted into fat, thereby contributing to a reduction in overall body fat. Consequently, SR9009 induces weight loss in diet-induced obese mice, a finding that has fueled interest in its potential for managing metabolic disordersChemotherapeutic Effect of SR9009, a REV-ERB Agonist .... Furthermore, SR9009 is being investigated for its role in treating metabolic diseases such as obesity.SR9009 | REV-ERBα/β agonist

Beyond its metabolic effects, SR9009 has also demonstrated an influence on circadian rhythms. Studies have shown that SR9009 can alter circadian locomotor activity and core clock hypothalamic gene expression in mice. This modulation of the body's internal clock has implications for understanding and potentially addressing sleep disorders and other conditions linked to disrupted circadian patternsSR 9009 (5855) by Tocris, Part of Bio-Techne. In some research contexts, SR9009 has been explored for its potential in managing anxiety and depressive disorders, although more extensive human studies are needed to confirm these effects.

The compound's designation as a research drug underscores its current status. While SR9009 is a synthetic REV-ERB agonist used for treatment with metabolic diseases, its availability is primarily for research purposes. It is important to note that SR9009 is not a selective androgen receptor modulator (SARM) but rather a distinct class of compound. As a small molecule which can act as a RevErb a/b agonist, its interactions are focused on the nuclear receptor pathway.

Emerging research also suggests SR9009 may have anti-inflammatory properties. Studies have indicated that SR9009 can decrease inflammation markers such as IL-6Stenabolic [Fast Facts] - Uses, Side Effects, and More. Additionally, some investigations have explored its impact on inflammation-related processes. There is also some preliminary research suggesting SR9009 might act as an estrogen receptor β agonist, though its primary and most well-documented action is as a REV-ERB agonist.

For researchers, SR9009 is often supplied as a powder and is available through various scientific supply companies. Purity levels typically exceed 99% by HPLC, making it suitable for laboratory experiments. While some results indicate SR9009 could potentially be used for weight loss, diabetes, and to improve athletic performance, it is crucial to emphasize that there is currently no substantial scientific evidence to support these uses in humans. The compound is considered brain penetrant, meaning it can cross the blood-brain barrier, which may contribute to its observed effects on behavior and gene expression in the hypothalamus.

In summary, SR9009 peptide, or Stenabolic, is a significant SR9009 agonist that functions by activating REV-ERB receptors. Its demonstrated ability to influence fatty acid and glucose metabolism, induce weight loss in animal models, and modulate circadian rhythms makes it a compelling subject for ongoing scientific investigation. While its potential applications are broad, it remains primarily a tool for research, with its use in humans not yet supported by robust clinical evidence.Sr9009, commonly known as Stenabolic, stands out as a synthetic compound categorized as a Rev-ErbA agonist rather than a selective androgen receptor modulator ...